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Malaria Vaccine UPSC NOTE

 Why in News

An inexpensive malaria vaccine developed by Oxford university and manufactured by Serum institute of India.


  • Malaria is a serious and sometimes fatal disease caused by a parasite.

  • People who get malaria are typically very sick with a high fever and shaking chills.

  • While the disease is uncommon in temperate climates.

  • Malaria is still common in tropical and subtropical countries.

  • Malaria is caused by a parasite of the genus Plasmodium.

  • There are five species of Plasmodium that can infect humans.

  • The most common and dangerous is Plasmodium falciparum.

  • The malaria parasite travels to the liver, where it matures and multiplies.

  • If malaria is not treated promptly, it can become severe and may cause kidney failure, seizures, mental confusion, coma, and death.

  • Malaria is a serious disease, but it is preventable and treatable.

R21/MatrixM malaria vaccine 

  • The R21/Matrix-M malaria vaccine is a pre-erythrocytic malaria vaccine.

  • Pre- erythrocytic means - being exoerythrocytic stages of a malaria parasite that occur before the red blood cells are invaded.

  • It is a subunit vaccine that targets the sporozoite stage of the malaria parasite.

  • Sporozoite  - first stage of the parasite to enter the human body after a mosquito bite.

  • The R21 vaccine is made up of a protein called NANP.

  • NANP is fused to a protein from the hepatitis B virus.

R21/MatrixM malaria vaccine 

  • The R21/Matrix-M vaccine is given as a three-dose series.

  • The R21/Matrix-M vaccine is a significant breakthrough in the fight against malaria.

  •  It is the first malaria vaccine to be recommended by the WHO for use in children.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Malaria Vaccine UPSC NOTE
Malaria Vaccine UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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