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Malaria Vaccines UPSC NOTE

 RTS,S malaria vaccine

  • RTS,S/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine

  • It is one of two malaria vaccines approved (the other is R21/Matrix-M). 

  • The RTS,S vaccine was the first to target a parasite

  • It was developed by the Walter Reed Army Research Institute after 30 years of intense research and approved by the World Health Organization in 2021.

  • It is being aimed at children under the age of 5, who make up about 80% of all malaria deaths in Africa

  • The world’s first routine vaccine programme using the RTS,S started in Cameroon in January 2024.

  • The country is offering the vaccine free of charge to all infants up to the age of six months. 

  • This has been described as a transformative chapter in Africa’s public health history.

R21/Matrix M

  • The R21/Matrix is a second-generation RTS,S vaccine

  • It was developed by Oxford University’s Jenner Institute and approved by the WHO in October 2023

  • The R21 vaccine is a significant improvement on the RTS,S vaccine, with 75% efficacy over a year

  • The production process is much less complicated, which means it can be manufactured in vast amounts. 

  • The R21/Matrix M vaccine is very cost-effective, projected to retail at $2-$4 a dose, comparable in price to other childhood vaccines used in Africa.

  • Demand for malaria vaccines is unprecedented; however, available supply of RTS,S is limited.  

  • The addition of R21 to the list of WHO-recommended malaria vaccines is expected to result in sufficient vaccine supply to benefit all children living in areas where malaria is a public health risk.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Malaria Vaccines UPSC NOTE
Malaria Vaccines UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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