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PIEZO2 UPSC NOTE

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  Why in news Ardem Patapoutian , Nobel laureate, demonstrated the PIEZO mechanosensitive channels through a tattoo that responded to press...

 Why in news

  • Ardem Patapoutian, Nobel laureate, demonstrated the PIEZO mechanosensitive channels through a tattoo that responded to pressure, highlighting their role in sensing touch and pressure.

What is PIEZO2 ?

  • PIEZO2 is a mechanosensitive ion channel discovered by Ardem Patapoutian and Bertrand Coste in 2010.

  • These ion channels respond specifically to mechanical pressure or force, unlike other channels that respond to voltage or chemical signals.

  • PIEZO2 channels are found in neurons and play a crucial role in our ability to sense touch, pain, proprioception (body positioning), interoception (internal state), and other physiological functions.

  • The channels are involved in bodily processes such as respiration, urination, blood vessel formation, and bone density regulation.

  • PIEZO2 is involved in sensing mechanical changes in various tissues, including adipose (fat) tissue and the gut.

Potential Applications of PIEZO2

  • PIEZO2 helps sense mechanical changes in adipose (fat) tissue, influencing metabolism and fat regulation.

  • PIEZO2 plays a role in how the body produces heat and processes fat, proteins, and carbohydrates.

  • PIEZO2 is crucial for maintaining intestinal stem cell activity and healthy gut architecture.

    • Disruption of PIEZO2 leads to severe intestinal issues, such as diarrhea and weight loss.

  • Understanding PIEZO2 could lead to new treatments for diseases like inflammatory bowel disease (IBD) and cancer.

  • PIEZO2 helps regulate the differentiation of stem cells, which is vital for tissue regeneration.

  • Targeting PIEZO channels may provide therapeutic solutions for conditions involving tissue degeneration.

  • PIEZO2 opens new avenues for understanding how mechanical forces impact cell behavior, leading to better treatments for various diseases.

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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: PIEZO2 UPSC NOTE
PIEZO2 UPSC NOTE
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