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Hematopoietic Stem Cells UPSC NOTE


  • Hematopoietic Stem Cells (HSCs) are a type of multipotent stem cell found in the bone marrow and blood.

  • They have the unique ability to differentiate into various types of blood cells, including red blood cells, white blood cells, and platelets.

  • HSCs play a crucial role in maintaining a continuous supply of new blood cells throughout an individual's life.

  • They are responsible for the process of hematopoiesis, which is the formation and development of blood cells.

  • HSCs are characterized by their self-renewal capacity, which means they can divide and produce more stem cells to replenish their population.

  • Bone marrow transplantation is an effective treatment for blood cell malignancies, but finding suitable donor bone marrow cells is challenging.

  • Researchers have developed a new approach by delivering mRNA (messenger RNA) directly into bone marrow stem cells to edit genetic defects and replace them with healthy blood cells.

  • This technique was demonstrated in living mice, where bone marrow stem cells were depleted, and healthy blood cells were repopulated.

  • The same technique was also applied to human hematopoietic stem cells taken from four patients.

  • The use of mRNA allows for precise genetic editing and holds promise for improving bone marrow transplantation and treating various blood-related diseases.

  • This innovative method has potential implications for regenerative medicine and could revolutionize the field of hematopoietic stem cell therapies.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Hematopoietic Stem Cells UPSC NOTE
Hematopoietic Stem Cells UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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