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The role of Y chromosome UPSC NOTE


  • Male mice showed a higher frequency of metastasis and worse survival outcomes, similar to humans.

  • The researchers identified an upregulated gene on the Y chromosome that contributes to colorectal cancer in males.

  • This gene is responsible for driving tumor invasion and aiding immune escape in colorectal cancer.

  • The Y chromosome, traditionally associated with male characteristics, has been implicated in cancer outcomes.


  • In bladder cancer, the loss of the Y chromosome is associated with poor prognosis and worse outcomes.

  • Loss of the Y chromosome leads to a more immunosuppressive tumor microenvironment in bladder cancer.

  • Tumors lacking the Y chromosome are more aggressive and show a dampened T cell-mediated immune response.

  • Loss of the Y chromosome is associated with increased response to anti-PD1 checkpoint blockade therapy in both mice and humans.


  • This suggests a potential line of treatment for a subset of bladder cancers characterized by Y chromosome loss.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: The role of Y chromosome UPSC NOTE
The role of Y chromosome UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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