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 What is Taxol?

  • Taxol, also known by its generic name paclitaxel, is a chemotherapy drug.

  • Taxol used  to treat a variety of cancers, including breast cancer, ovarian cancer, lung cancer, and Kaposi's sarcoma. 

  • It is a natural compound that is extracted from the bark of the Pacific yew tree.

  • Taxol works by stopping cancer cells from dividing. 

  • When the microtubules are disrupted, the cancer cells cannot divide and eventually die.

Permeability glycoprotein

  • Permeability glycoprotein (P-gp) is a membrane protein that pumps drugs out of cells. 

  • It is also known as multidrug resistance protein 1 (MDR1) or ABCB1. 

  • P-gp is found in many different types of cells, including cancer cells, blood-brain barrier cells, and intestinal cells.

  • P-gp can make it difficult for chemotherapy drugs to reach cancer cells. 

  • This is because P-gp pumps the drugs out of the cancer cells before they can have a chance to work. 

Permeability glycoprotein

  • P-gp can also make it difficult for other types of drugs, such as HIV drugs, to reach their target tissues.

  • There are a number of different ways to overcome P-gp resistance. 

  • One way is to use drugs that block P-gp. 

  • These drugs are called P-gp inhibitors. 

  • P-gp resistance is to use drugs that are designed to be resistant to P-gp. 

  • These drugs are called P-gp substrates.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Taxol UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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