Download Learnerz IAS app from the Play Store now! Download



Rheumatoid Arthritis UPSC NOTE

 What is Rheumatoid Arthritis

  • It is a chronic, autoimmune condition that mostly affects the joints

  • Scientists have not yet understood why an autoimmune condition occurs, allowing the immune system that protects the body, to attack itself

  • A patient experiences pain, swelling of joints and loss of function and mobility as a result of stiffness. 

  • As can be expected, this is likely to significantly lower a patient’s quality of life

  • As per the National Institute of Arthritis and Musculoskeletal and Skin Diseases, of the National Institutes of Health, U.S., rheumatoid arthritis affects the lining of the joints, and damages the tissue that covers the ends of the bones in a joint. 

  • It often occurs in a symmetrical pattern, meaning that if one knee or hand has the condition, the other hand or knee is also often affected

  • Fatigue, occasional fevers, and a loss of appetite are to be expected, and there is a possibility that it may cause medical problems outside of the joints including in the heart, lungs, blood nerves, eyes and skin.

Anticitrullinated peptide antibodies (ACPAs)

  • Anticitrullinated peptide antibodies (ACPAs) are a specific type of autoantibody, meaning they are antibodies produced by the immune system that mistakenly target the body's own tissues

  • In the case of ACPAs, they target proteins that have undergone a chemical modification called citrullination.

  • Autoantibodies against citrullinated proteins.

  • Can contribute to the inflammatory process in certain autoimmune diseases, particularly rheumatoid arthritis (RA).

  • Through a blood test called an anti-CCP antibody test.

  • They are highly specific for RA and can be helpful in diagnosis, especially in early stages of the disease.

  • Citrullination is a natural chemical reaction that converts the amino acid arginine into citrulline in proteins.

  • This modification can occur due to various factors, including inflammation and cell death.

  • While generally harmless, citrullinated proteins can sometimes be misidentified as foreign by the immune system, leading to the production of ACPAs.



Amritsar,1,April 2024,117,Art & Culture,1,August 2023,251,Courses,7,Daily Current Affairs,48,December 2023,189,Disaster Management,2,Environment and Ecology,54,February 2024,228,Foundation Course,1,GDP,1,GEMS Club,1,GEMS Plus,1,Geography,67,Govt Schemes,2,GST,1,History,2,Home,3,IAS Booklist,1,Important News,71,Indian Economy,46,Indian History,2,Indian Polity,56,International Organisation,12,International Relations,58,Invasive Plant,1,January 2024,240,July 2023,281,June 2022,6,June 2023,268,March 2024,238,May 2022,17,Mentorship,2,November 2023,169,October 2023,203,Places in News,2,Science & Technology,66,September 2023,205,UPSC CSE,111,
Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Rheumatoid Arthritis UPSC NOTE
Rheumatoid Arthritis UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share to a social network STEP 2: Click the link on your social network Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy Table of Content