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Scientists have made new discoveries about how an inflammatory form of cell death may drive rheumatoid arthritis.
According to experiments involving mice and samples from patients.
The findings implicate a protein named ALOX5 as a key player in this autoimmune disorder.
It suggest it could serve as both a treatment target and a potential marker of active disease and remission.
T cells from patients contained high amounts of the enzyme ALOX5.
ALOX5
Scientists have made new discoveries about how an inflammatory form of cell death may drive rheumatoid arthritis.
According to experiments involving mice and samples from patients.
The findings implicate a protein named ALOX5 as a key player in this autoimmune disorder.
It suggest it could serve as both a treatment target and a potential marker of active disease and remission.
T cells from patients contained high amounts of the enzyme ALOX5.
ALOX5, also known as arachidonate 5-lipoxygenase, is a non-heme iron-containing enzyme found in humans and other animals.
It plays a crucial role in the body's inflammatory response by producing various lipid mediators called leukotrienes.
Constricting airways in the lungs, contributing to asthma symptoms.
Increasing blood vessel permeability, leading to swelling.
Attracting immune cells to the site of inflammation
Encoded by the ALOX5 gene located on chromosome 17 in humans.
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