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ALOX5 UPSC NOTE

 Why in News

  • Scientists have made new discoveries about how an inflammatory form of cell death may drive rheumatoid arthritis.

  • According to experiments involving mice and samples from patients

  • The findings implicate a protein named ALOX5 as a key player in this autoimmune disorder.

  • It suggest it could serve as both a treatment target and a potential marker of active disease and remission

  • T cells from patients contained high amounts of the enzyme ALOX5.

ALOX5

  • Scientists have made new discoveries about how an inflammatory form of cell death may drive rheumatoid arthritis.

  • According to experiments involving mice and samples from patients

  • The findings implicate a protein named ALOX5 as a key player in this autoimmune disorder.

  • It suggest it could serve as both a treatment target and a potential marker of active disease and remission

  • T cells from patients contained high amounts of the enzyme ALOX5.

  • ALOX5, also known as arachidonate 5-lipoxygenase, is a non-heme iron-containing enzyme found in humans and other animals

  • It plays a crucial role in the body's inflammatory response by producing various lipid mediators called leukotrienes

  • Constricting airways in the lungs, contributing to asthma symptoms.

  • Increasing blood vessel permeability, leading to swelling.

  • Attracting immune cells to the site of inflammation

  • Encoded by the ALOX5 gene located on chromosome 17 in humans.

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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: ALOX5 UPSC NOTE
ALOX5 UPSC NOTE
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Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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