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 Why in news

  • India is getting closer to developing a gene therapy for sickle cell disease, a genetic blood disorder with a high prevalence rate among the Scheduled Tribes, officials of the Union Tribal Affairs Ministry said

  • M. Srinivas, Director of the All India Institute of Medical Sciences (AIIMS), said researchers were working to develop a gene therapy using CRISPR-Cas9, a gene-editing tool.

What is CRISPR-Cas9?

  • CRISPR/Cas9 is a gene-editing technology which involves two essential components: a guide RNA to match a desired target gene, and Cas9 (CRISPR-associated protein 9)—an endonuclease which causes a double-stranded DNA break, allowing modifications to the genome 

  • The CRISPR-Cas9 system consists of an enzyme that behaves like molecular scissors, which can be directed to cut a piece of DNA at a precise location

  • This will then allow a guide RNA to insert a changed genetic code at the sites of the incision.

  • While there are a few ways to effect such changes, the CRISPR system is believed to be fast and the most versatile of all.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: CRISPR-Cas9 UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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