False
Download Learnerz IAS app from the Play Store now! Download

$show=search/label/May%202022

 


Inflammatory bowel disease UPSC NOTE

 Inflammatory bowel disease

  • Inflammatory bowel disease (IBD) is a term that describes disorders involving long-standing (chronic) inflammation of tissues in your digestive tract. Types of IBD include:

Ulcerative colitis

  • This condition involves inflammation and sores (ulcers) along the lining of your large intestine (colon) and rectum.

Crohn's disease

  • This type of IBD is characterized by inflammation of the lining of the digestive tract, which often can involve the deeper layers of the digestive tract. 

  • Crohn's disease most commonly affects the small intestine. 

  • However, it can also affect the large intestine and uncommonly, the upper gastrointestinal tract.

  • Both ulcerative colitis and Crohn's disease usually are characterized by diarrhea, rectal bleeding, abdominal pain, fatigue and weight loss

Causes

  • Researchers at Francis Crick Institute, in collaboration with UCL and Imperial College London published their findings in journal Nature about causes of IBD. 

  • Scientists at the Crick journeyed into a ‘gene desert’ — an area of DNA that doesn’t code for proteins — which has previously been linked to IBD and several other autoimmune diseases.

  • They found that this gene desert contains an ‘enhancer’, a section of DNA that is like a volume dial for nearby genes, able to crank up the amount of proteins they make. 

  • The team discovered that this particular enhancer was only active in macrophages, a type of immune cell known to be important in IBD, and boosted a gene called ETS2, with higher levels correlating with a higher risk of disease.

  • Using genetic editing, the scientists showed that ETS2 was essential for almost all inflammatory functions in macrophages, including several that directly contribute to tissue damage in IBD

  • The team also discovered that many other genes previously linked to IBD are part of the ETS2 pathway, providing further evidence that it is a major cause of IBD.


COMMENTS

Name

Amritsar,1,April 2024,301,Art & Culture,1,August 2023,251,Courses,7,Daily Current Affairs,48,December 2023,189,Disaster Management,2,Environment and Ecology,154,February 2024,228,Foundation Course,1,GDP,1,GEMS Club,1,GEMS Plus,1,Geography,158,Govt Schemes,2,GS 2,1,GS1,6,GS2,41,GS3,16,GST,1,History,9,Home,3,IAS Booklist,1,Important News,71,Indian Economy,123,Indian History,4,Indian Polity,137,International Organisation,12,International Relations,107,Invasive Plant,1,January 2024,240,July 2023,281,June 2022,6,June 2023,268,June 2024,220,March 2024,238,May 2022,17,May 2024,330,Mentorship,2,November 2023,169,October 2023,203,Places in News,2,Science & Technology,75,Science and Technology,90,September 2023,205,UPSC CSE,111,
ltr
item
Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Inflammatory bowel disease UPSC NOTE
Inflammatory bowel disease UPSC NOTE
https://lh7-us.googleusercontent.com/slidesz/AGV_vUeQRG7LzuuR6yEFnkDgbY9cgegtA_-pILFJ7RVgw8Oe11tL6Ow5iYSNXPgonuV15krx5u1m-EMMbkkB_ZVKfbBsYKEj__H4Ukd0rgtOgeB4Q2w2wC2cEQz5NMJzju3idAUlYoo5kMuRMEs5eSnbA_p4wbDetsziVv_p76A-J97J2Q=s2048?key=RnxBqnGfmnJPawFmas9oSA
https://lh7-us.googleusercontent.com/slidesz/AGV_vUeQRG7LzuuR6yEFnkDgbY9cgegtA_-pILFJ7RVgw8Oe11tL6Ow5iYSNXPgonuV15krx5u1m-EMMbkkB_ZVKfbBsYKEj__H4Ukd0rgtOgeB4Q2w2wC2cEQz5NMJzju3idAUlYoo5kMuRMEs5eSnbA_p4wbDetsziVv_p76A-J97J2Q=s72-c?key=RnxBqnGfmnJPawFmas9oSA
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
https://www.learnerz.in/2024/06/inflammatory-bowel-disease-upsc-note.html
https://www.learnerz.in/
https://www.learnerz.in/
https://www.learnerz.in/2024/06/inflammatory-bowel-disease-upsc-note.html
true
4761292069385420868
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share to a social network STEP 2: Click the link on your social network Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy Table of Content