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Sickle Cell Anaemia UPSC NOTE

 June 19 : World Sickle Cell Awareness Day

Why in news

  • Sickle Cell Disease (SCD) remains a formidable challenge in the landscape of global health, particularly in places like India, where its burden is significant, particularly among tribal populations

  • SCD affects 20 million people worldwide. India grapples with a formidable challenge posed by SCD, with millions affected

Sickle cell anemia

  • Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders typically inherited.

  • The most common type is known as sickle cell anemia.

  • It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells.

  • This leads to a rigid, sickle-like shape under certain circumstances.

  • Problems in sickle cell disease typically begin around 5 to 6 months of age.

  • A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis) in joints, anemia, swelling in the hands and feet, bacterial infections, dizziness and stroke.

  • It often gets worse with age

  • All the major organs are affected by sickle cell disease.

  • Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene (HBB) that makes haemoglobin, one from each parent.

  • This gene occurs in chromosome 11.

  • Several subtypes exist, depending on the exact mutation in each haemoglobin gene

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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Sickle Cell Anaemia UPSC NOTE
Sickle Cell Anaemia UPSC NOTE
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