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Amphotericin B UPSC NOTE

 Amphotericin B

Why in News

  • A structurally modified antifungal agent has shown reduced toxicity in mice and in human kidney cells while retaining its antimicrobial properties.

  • The advance could increase the clinical effectiveness and safety of such treatments in fighting deadly fungal infections.

What is Amphotericin B (AmB)

  • Amphotericin B (AmB) is a broad-spectrum antifungal medication used to treat a variety of serious fungal infections. 

  • It is a polyene antibiotic that works by binding to ergosterol, a component of the fungal cell membrane. 

  • This binding creates pores in the cell membrane, which allows ions and other molecules to leak out, leading to cell death.

  • AmB is a very effective antifungal medication, but it is also very toxic. 

  • The most common side effects of AmB are infusion-related reactions, such as chills, fever, nausea, vomiting, and hypotension

  • More serious side effects can include nephrotoxicity (kidney damage), hepatotoxicity (liver damage), and bone marrow suppression.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Amphotericin B UPSC NOTE
Amphotericin B UPSC NOTE
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