R21/Matrix-M UPSC NOTE

 Why in News

  • The World Health Organization on Thursday added the R21/Matrix-M malaria vaccine, developed by Oxford University and manufactured by Serum Institute of India, to its list of prequalified vaccines

  • In October 2023, the WHO had recommended its use for the prevention of malaria in children.

  • The R21 vaccine is the second malaria vaccine prequalified by the WHO.


  • The R21/Matrix-M is a promising new malaria vaccine that recently received a recommendation

for use in children from the World Health Organization (WHO). 

  • R21/Matrix-M is a subunit vaccine, meaning it contains specific protein fragments from the malaria parasite instead of the whole organism

  • This makes it safer and more stable than traditional whole-organism vaccines.

  • The R21 component targets a protein on the surface of the parasite's "sporozoite" stage, the form injected by mosquitoes and the first to invade the human liver.

  • The Matrix-M component is an adjuvant, a substance that enhances the immune response to the vaccine

  • It's a saponin-based adjuvant developed by Novavax and licensed to the Serum Institute of India for use in endemic countries.



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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: R21/Matrix-M UPSC NOTE
R21/Matrix-M UPSC NOTE
Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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