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Nickel Exposure & Sterol Biosynthesis UPSC NOTE

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  Why in news Researchers from the University of Georgia discovered a new connection between nickel exposure and sterol biosynthesis in both...

 Why in news

  • Researchers from the University of Georgia discovered a new connection between nickel exposure and sterol biosynthesis in both fungi and mammalian cells.

  • This finding challenges previous beliefs that nickel toxicity and sterol production were unrelated.

New discovery

  • Exposure to nickel in fungi and mammalian cells caused sterol deficiencies, which are important for cell membrane integrity.

  • Nickel tolerance in fungi was linked to a gene (ERG25), which helps cells tolerate nickel by increasing sterol biosynthesis.

  • The study uncovered that the absence of the SRE1 protein (in humans called, sterol regulatory element binding protein (SREBP)) which regulates sterol production, made fungal cells highly sensitive to nickel.

  • Nickel exposure also reduces cholesterol in human cells, similar to its effect on fungi. 

  • This connection could help develop new antifungal treatments.

  • Targeting the ERG25 gene might lead to new drugs that both reduce nickel toxicity and fight fungal infections.

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Learnerz IAS | Concept oriented UPSC Classes in Malayalam: Nickel Exposure & Sterol Biosynthesis UPSC NOTE
Nickel Exposure & Sterol Biosynthesis UPSC NOTE
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Learnerz IAS | Concept oriented UPSC Classes in Malayalam
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